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Recently, Louisville has surfaced as a major gathering place for the health care and healthcare sciences sectors. Louisville has been core to developments in heart and hand operation as well as cancer medication. A few of the first man-made coronary heart transplants were performed in Louisville. Louisville's booming downtown medical research university involves the innovative $Eighty-eight million rehab heart, and a well being sciences study and commercialization recreation area which, in joint venture with the University of Louisville, has lured nearly 80 top scientists and investigators. Louisville is also residence to Humana, just one of the nation's most significant health insurance policies businesses.

Louisville is residence to many major firms and agencies.